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| LT012: | β-N-Oxalyl-L-α ,β -Diaminopropionic acid (L-ODAP)
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HOOC.CO.NH.CH2.CH.(NH2).COOH |
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Unusual amino
acid from Lathryus sativus seeds with demonstrable
neurotoxicity in experimental animals(1-4) an Inhibitor of Tryosine
amino transaminase(5) and is the only known naturally occuring
compound to inhibit this enzyme and a putative non NMDA receptor
agonist (6-8) and inhibits mitochondrial complex I in the CNS(9). |
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LT013: |
β-N-Oxalyl-D-α ,β -Diaminopropionic acid (D-ODAP)
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HOOC.CO.NH.CH2.CH.(NH2).COOH |
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A non neurotoxic isomer of L-ODAP(10). |
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LT014: |
L- α, β-Diaminopropionic acid
HCl (L-DAP)
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NH2.CH2CH.(NH2).COOH |
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A nontoxic amino acid but can inhibit glutamate binding to synpatic membranes(8). |
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LT015: |
D- α,β -Diaminopropionic acid
HCl (D-DAP)
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NH2.CH2CH.(NH2).COOH |
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A constituent of some antibiotics and inhibitor of microbial growth. |
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LT016: |
β-N-Acetyl-L-α,β -Diaminopropionic acid (ADAP) |
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CH3.CO.NH.CH2.CH.(NH2).COOH |
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A nonneurotoxic analogue of ODAP but can pontentiate NMDA evoked currents(11). |
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LT017: |
β-N-Carboxymethyl L-α,β -Diaminopropionic acid(CMDAP)
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HOOC.CH2.NH.CH2.CH.(NH2).COOH |
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A nonneurotoxic analogue of ODAP but can activate sensitive NMDA Receptors(11). |
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LT018: |
γ-N-Oxalyl-L-α, γ-Diaminobutyric acid (L-ODAB)
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HOOC.CO.NH.CH2.CH2.CH.(NH2).COOH |
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| A neuroactive principle found in some lathryus species and presumably acts at certain receptor in the CNS. | |
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